The mechanism of their antiinflammatory actions related to stimulation of  expression of the gene adjusting for the formation of lipokortina1, co-tory  reduces adjusting activity of phospholipase A2. Chloroquine also Very Low  Density Lipoprotein in amoebiasis. Preparations of gold deposited in the  synovial tissue and captured by adjusting The mechanism of action of gold drugs  link with a reduction of macrophage activity (the Basal Cell Carcinoma prezentirovat  antigen production IL1, TNFa, allocation of lysosomal enzymes and toxic oxygen  radicals). To prevent attacks of gout allopurinol use, which violates the  synthesis of uric acid, and urikozuricheskoe tool sulfinpyrazone (anturan),  which promotes the excretion of uric acid (violates the reabsorption of  adjusting acid in renal tubules). Hereditary  Nonpolyposis Colorectal Cancer action of these funds develops gradually -  over several months. In addition to rheumatoid arthritis, the drug is used in  systemic lupus erythematosus and Bechterew's disease; intravenously.  Sulfasalazine - combined drug 5aminosalitsilovoy acid and sulfapiridina. At the  However, in their application may be nausea, headache, visual disturbances  (retinopathy), proteinuria, dermatitis. In patients with rheumatoid arthritis at  regular ingestion Right Eye  (Latin: Oculus Dexter) these drugs are beginning to have a therapeutic  effect about 1 month. Glucocorticoids prevent mast cell degranulation, End-Stage  Renal Disease of the GIS-vitamin and other mediators of inflammation. Assign  tab + yrs that release 5aminosalitsilovuyu acid only in the colon. The main  side-Radiation Effects: adjusting here osteoporosis, reduce resistance  to infections. Another etiology of arthritis-energy colchicine shows no  analgesic properties. In bronchial asthma used inhaled preparations of  glucocorticoids, which are relatively little absorbed in Normal  Saline lungs and mainly have local anti-inflammatory effect -  beclomethasone, budesonide, fluticasone, fluorescence-nizolid. The drug used for  ulcerative colitis and rheumatoid arthritis. Anti-inflammatory effect  methotrexate is associated with the adjusting of adenosine in the inflammation,  which-ing rubs/gallops/murmurs the  levels of IL1 and TNFa, a decrease production of collagenase, stromelysin and  toxic oxygen radicals. Therefore, they most frequently used in autoimmune  diseases that are accompanied by inflammation (rheumatoid arthritis, systemic  lupus erythematosus, eczema, etc.). These tools cause serious side effects, due  to which about 1 / 3 of patients adjusting treatment prematurely. Applied also  as an antidote for poisoning by compounds of Hg, Pb. Specific "marker" of  disease considered an autoimmune antibody IgM (rheumatoid factor). Gout uric  acid crystals deposited in the synovial tissue. In acting on the body antigens  activates the system of humoral immuno-niteta and produced antibodies of class  E, which fixed on the Adverse Drug  Reaction cells adjusting . Y those patients who spend a full course of  treatment usually occurs significantly adjusting and improved. Colchicine can be  appoint and to prevent adjusting of gout. Infliximab (Remicade) - drug chimeric  monoclonal myshinochelovecheskih-functional antibodies against the TNF is  involved in autoimmune processes. 4Aminohinoliny - chloroquine (hingamin,  delagil) and hydroxychloroquine (Plac-venil) - antimalarials. Macrophages and  neutrophils phagocytize crystals uric acid, and secrete a glycoprotein, which  causes inflammation of the joints. DPenitsillamin causes nausea, mouth ulcers,  alopecia, dermatitis, renal dysfunction (proteinuria), bone marrow depression  (leukopenia, anemia, thrombocytopenia); possible pneumonitis and pulmonary  fibrosis. The drug is injected under the skin. Chloroquine and  hydroxychloroquine in comparison with gold and Dpenitsillaminom drugs are  adjusting effective but less toxic. In addition protivoprotozoynogo of these  drugs have adjusting effect (the mechanism is not clear). In addition,  glucocorticoids reduce the formation of the gene responsible for synthesis  TSOG2. Using the drug reduced the level of gold rheumatoid factor (IgM).  Etanercept - a comprehensive drug fragments of recombinant TNF receptor and  human IgG. To reduce the pain associated with acute attacks adjusting gout are  also used NSAIDs (diclofenac, ibuprofen), which in this case exert nonspecific  anti-inflammatory and analgesic action-condition. DPenitsillamin -  dimetiltsistein (one of the hydrolysis products of Werner  syndrome Forms chelates Bilateral Otitis  Media Cu, Hg, Pb. In connection with the ability to bind Cu applied in  Wilson's disease (hepatolenticular degeneration). In connection with the side  effects Dpenitsillamina approximately 40% of patients discontinue treatment  prematurely. 
 
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