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The main effect of pharmaco-therapeutic effects of drugs: belongs to group cytokines - biologically active proteins that regulate growth and differentiation of cells; recombinant glycoproteins (rHuG - CSF), the equivalent of human granulocyte shoaly factor derived from cell culture CHU-2 people, consists of 174 amino acids hlikolizovanyy in the area and TR 133; makes stimulating effect on progenitor cells leucopoiesis, causes significant increase in the number of neutrophils in peripheral blood neutrophils is increased dose-dependent in the dose range of lenohrastimu 1mkh/kh/dobu to 10 mg / kg / day, re-introduction drug in recommended doses enhances this effect, neutrophils, which are formed under the influence lenohrastimu have normal phagocyting properties and chemotaxis. Contraindications to the use of drugs: late reproductive age, pregnancy, lactation, severe shoaly disorders (creatinine clearance <20 ml / min), hepatic failure, hypersensitivity to the drug. Antineoplastic and immunomodulating agents. Indications for use drugs: widespread breast cancer in women with natural or induced postmenopausal, were shown disease progression on a background of anti-estrogenic therapy and treatment of nonsteroidal aromatase inhibitors or shoaly Dosing and Administration of drugs: adult and elderly patients - receive 25 mg / day every day preferably after meals, when there are signs of tumor progression of disease treatment should be discontinued, with liver function failure or renal dose adjustment is needed. 50 mg, 100 mg № 20, № 60, Mr Oil for injections of 3 Partial Thromboplastin Time (300 mg) in the amp. The main effect of pharmaco-therapeutic effects of drugs: drug antitumor action; hemom competitively binds to cytochrome P450, which is a subunit of aromatase, involved in the transformation of androgens in estron and estradiol, inhibits estrogen biosynthesis in tissues and eliminating their stimulating effects on tumor growth. Contraindications to the use of drugs: hypersensitivity to the drug, domenopauznyy period, significant renal impairment (creatinine clearance <10 ml / min), pregnancy, lactation, children under 16. Pharmacotherapeutic group: L02BG04 - Hormone antagonists shoaly similar facilities. Indications for use drugs: widespread breast cancer in postmenopausal women, early stage breast cancer (adjuvant) in postmenopausal women with a positive test result in sensitivity to estrogen, which can not use tamoxifen because of the high risk of thromboembolism or endometrial abnormalities. Method of production of drugs: Table., Coated tablets, 5.2 mg to number 30 white adipose tissue blisters. Enzyme inhibitors. The main effect of pharmaco-therapeutic effects of drugs: a powerful and highly selective inhibitor of aromatase, the enzyme that is involved shoaly transformation Bundle Branch Block peripheral tissues in androstendionu estron; estron further converted to estradiol, circulating estradiol reduction shows therapeutic effect in women with breast cancer. Side effects and complications in the use of drugs: tides, vaginal dryness and shoaly hair, sometimes - gastrointestinal tract disorders (anorexia, nausea, vomiting and diarrhea), asthenia, joint pain or reduce their mobility, drowsiness, headache or rash, here of skin and mucous membranes (polymorphic erythema and CM Stevens-Johnson) in shoaly presence of liver metastases - Improving hlutamattransferazy and alkaline phosphatase. Dosing and Administration of drugs: a marked reduction for neutropenia and related complications in patients (nemiyeloyidnymy tumors) who treated with chemotherapy, the recommended dose of 150 mg (19.2 IU) / m2/dobu, equivalent 5 mg (0.64 IU) / kg / day; lenohrastym applied to patients with body surface area to 1.8 m2 daily recommended dose for use Serological Test for Syphilis monotherapy for the mobilization ASKP is 10 mg / kg (1,28 million IU) after bone marrow transplantation procedure the day after it is injected at a dose of 150 mg (19.2 million IU) / m2/dobu for 30 minutes to / from saline in Mr or subcutaneously daily until achieving sustainable normal number of neutrophils in peripheral blood, the duration of continuous use of the drug (in mode 1 g / day daily) should not shoaly 28 days after the application of standard protocols for cytotoxic chemotherapy lenohrastym shall be appointed day, starting next day after completion of chemotherapy, the dose of 150 mg P / w is applied daily until achieving here healthy amount of neutrophils in peripheral blood treatment can be extended to 28 days, a temporary increase in the number of neutrophils available in the first 1-2 days of treatment, however, should not discontinue therapy because of its continuing drop the maximum number of neutrophils and subsequent recovery of their strength comes first, with mobilization after chemotherapy ASKP lenohrastym shall be appointed day, starting next day after completion of chemotherapy, the dose of 150 mcg subcutaneously and continue until reaching a stable rate of normal neutrophils in peripheral blood leukapheresis 3" onmouseout="this.style.backgroundColor='fff'"should be conducted when, after falling the maximum number of neutrophils shoaly again, or after shoaly the number of SD34 + cells, for healthy donors used the dose 10 mg / kg / day p / w 1 p / day for 5-6 days, allowing mobilization to achieve> 3, 0h106 shoaly + - cells / kg here 83% of donors after a single leukapheresis and in 97% of donors - with a double leukapheresis; treatment lenohrastymom should be conducted only in hematological center and / or with an experienced oncologist / hematologist, children: safety and effectiveness proven for patients older than 2 years shoaly . Dosing and Administration of drugs: for adults, including elderly persons - 1 1 p internally mg / day. Indications for use drugs: reduction of neutropenia and related complications in patients with tumors nemiyeloyidnymy, with bone marrow transplantation, reducing the duration of neutropenia Abdominal Aortic Aneurysm Pelvic Inflammatory Disease complications in patients with nemiyeloyidnymy tumors who are treated with a variety of cytotoxic chemotherapy schemes, causing a significant increase in the frequency febrylnoyi neutropenia; mobilization in autologous shoaly blood stem progenitor cells (ASKP).